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Generic Cialis or Tadalafil is a drug used in treatment of impotence. This is taken orally. Impotence means a condition where the patient doesn't get a good penile erection. Tadalafil is included in class named phosphodiesterase inhibitor. The same class or so includes vardenafil (Levitra) and sildenafil (Viagra). Penile erection is caused by more blood filling in the penis.

More blood fills the penis because the blood vessels that bring blood to the penis increase in size and bring more blood and at the same time removal of blood reduces due to reduction in the size of the blood vessels taking blood out of the penis. Due to sexual stimulation, erection happens. Such stimulation helps in production and releasing of nitric oxide. When nitric oxide is released in the penis, it helps guanylate cyclase enzyme in production of cyclic guanosine monophosphate (cGMP). cGMP is important because it can manipulate the size of the blood vessels carrying blood to and from the penis. Filling in more blood in the penis, results in erection.

When phosphodiesterase-5 enzyme prevents cGMP, then the erection ends because blood vessels come to their normal sizes and then excess blood is drained out of the penis. Tadalafil important here because it prevents phosphodiesterase-5 from destroying cGMP, which means penile erection can stay longer. Tadalafil got the approval from FDA in November 2003. To buy generic cialis from drug stoe prescription is needed. STORAGE: Store at room temperature between 15-30 C (59-86 F). PRESCRIBED FOR: Tadalafil is prescribed for people who are suffering from impotence or erectile dysfunction, ED.

DOSING: doctors recommend tadalafil 10 mg per day dose for most of the patients. It is to be taken before sex. That dose can be increased or decreased depending on the side effect and the response of the drug to the patient. The maximum limit is 20 mg and the minimum is 5 mg per day. For patients taking other medications, doctors recommend that that dose should not exceed 10 mg in 72 hours. Tadalafil absorption is not affected by food and so it can be taken with food or without it.

Tadalafil activity can be affected by certain other elements as they hamper breakdown and elimination of the medicine. Such elements include erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir) etc. In that case, the level of Tadalafil will be increased in the bloodstream. This is why; these drugs should not be used at the same time as tadalafil, if possible. If you need to use them, it is important to reduce dose of Tadalafil to avoid side effects. Tadalafil can increase the effects of nitrates, which include higher heart rate and lower blood pressure.

Nitroglycerin, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur, Ismo, Monoket), nitroglycerin (Nitro-Dur, Transderm-Nitro) are some of the drugs used in heart pain or angina medications. In those people, tadalafil can result in heart pain or heart attack due to its affects when combined with nitrates. So, you should not use tadalafil with nitrates.

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